Article
Prognostic value of BRAF and KRAS mutation status in stage II and III microsatellite instable colon cancers.
International journal of cancer - 1 Mar 2016
de Cuba E M V, Snaebjornsson P, Heideman D A M, van Grieken N C T, Bosch L J W, Fijneman R J A, Belt E, Bril H, Stockmann H B A C, Hooijberg E, Punt C J A, Koopman M, Nagtegaal I D, Coupé V H M, Carvalho B, Meijer G A
Abstract excerpt
Microsatellite instability (MSI) has been associated with favourable survival in early stage colorectal cancer (CRC) compared to microsatellite stable (MSS) CRC. The BRAF V600E mutation has been associated with worse survival in MSS CRC. This mutation occurs in 40% of MSI CRC and it is unclear whether it confers worse survival in this setting. The prognostic value of KRAS mutations in both MSS and MSI CRC remains...
Topics
- Adult
- Aged
- Aged, 80 and over
- Colonic Neoplasms
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Mutation