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Article

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer.

British journal of cancer - 9 Jun 2015

Seppälä T T, Böhm J P, Friman M, Lahtinen L, Väyrynen V M J, Liipo T K E, Ristimäki A P, Kairaluoma M V J, Kellokumpu I H, Kuopio T H I, Mecklin J-P

Abstract excerpt

BACKGROUND: The objective of the study was to examine the role of microsatellite instability (MSI) and BRAF(V600E)mutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. METHODS: Tumour samples from 762 population-based patients with sporadic CRC were analysed for MSI and BRAF(V600E) by immunohistochemistry. Patient survival was followed-up for a...

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PMID: 25973534
DOI: 10.1038/bjc.2015.160
PMCID: PMC4580394

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BRAF

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