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Article

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer.

British journal of cancer - 9 Jun 2015

Seppälä T T, Böhm J P, Friman M, Lahtinen L, Väyrynen V M J, Liipo T K E, Ristimäki A P, Kairaluoma M V J, Kellokumpu I H, Kuopio T H I, Mecklin J-P

Abstract excerpt

BACKGROUND: The objective of the study was to examine the role of microsatellite instability (MSI) and BRAF(V600E)mutation in colorectal cancer (CRC) by categorising patients into more detailed subtypes based on tumour characteristics. METHODS: Tumour samples from 762 population-based patients with sporadic CRC were analysed for MSI and BRAF(V600E) by immunohistochemistry. Patient survival was followed-up for a...

Topics

Aged
Aged, 80 and over
Colorectal Neoplasms
Female
Humans
Male
Microsatellite Instability
Middle Aged
Mutation
Prognosis
Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 25973534
DOI: 10.1038/bjc.2015.160
PMCID: PMC4580394

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25973534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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