The prognostic role of microsatellite instability, codon-specific KRAS, and BRAF mutations in colon cancer.

doi:10.1002/jso.23675

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Article

The prognostic role of microsatellite instability, codon-specific KRAS, and BRAF mutations in colon cancer.

Journal of surgical oncology - 1 Sept 2014

Lin Chun-Chi, Lin Jen-Kou, Lin Tzu-Chen, Chen Wei-Shone, Yang Shung-Haur, Wang Huann-Sheng, Lan Yuan-Tzu, Jiang Jeng-Kai, Yang Muh-Hwa, Chang Shih-Ching

Abstract excerpt

BACKGROUND: This study aimed to establish a correlation between MSI, KRAS mutations, and BRAF(V600E) in colon cancer and to investigate the prognostic effect. METHODS: Colon cancer patients who underwent surgical intervention were enrolled. MSI status was identified by genotyping, and the mutatio...

Topics

Aged
Codon
Colonic Neoplasms
Female
Humans
Male
Microsatellite Instability
Middle Aged
Mutation
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 24964758
DOI: 10.1002/jso.23675

Genes

KRAS
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24964758-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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