Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer.

doi:10.1093/jnci/djw272

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Article

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer.

Journal of the National Cancer Institute - 1 May 2017

Taieb Julien, Le Malicot Karine, Shi Qian, Penault-Llorca Frédérique, Bouché Olivier, Tabernero Josep, Mini Enrico, Goldberg Richard M, Folprecht Gunnar, Luc Van Laethem Jean, Sargent Daniel J, Alberts Steven R, Emile Jean Francois, Laurent Puig Pierre, Sinicrope Frank A

Abstract excerpt

Background: The prognostic value of BRAF and KRAS mutations within microsatellite-unstable (MSI) and microsatellite-stable (MSS) subgroups of resected colon carcinoma patients remains controversial. We examined this question in prospectively collected biospecimens from stage III colon cancer with separate analysis of MSI and MSS tumors from patients receiving adjuvant FOLFOX +/- cetuximab in two adjuvant therapy...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Cetuximab
Chemotherapy, Adjuvant
Colectomy
Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Mismatch Repair

Female

Fluorouracil

Humans

Leucovorin

Male

Microsatellite Instability

Middle Aged

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 28040692
DOI: 10.1093/jnci/djw272
PMCID: PMC6075212

Genes

BRAF
KRAS
TTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28040692-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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