Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

doi:10.1200/JCO.2009.23.3452

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Article

Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jan 2010

Roth Arnaud D, Tejpar Sabine, Delorenzi Mauro, Yan Pu, Fiocca Roberto, Klingbiel Dirk, Dietrich Daniel, Biesmans Bart, Bodoky György, Barone Carlo, Aranda Enrique, Nordlinger Bernard, Cisar Laura, Labianca Roberto, Cunningham David, Van Cutsem Eric, Bosman Fred

Abstract excerpt

PURPOSE: Mutations within the KRAS proto-oncogene have predictive value but are of uncertain prognostic value in the treatment of advanced colorectal cancer. We took advantage of PETACC-3, an adjuvant trial with 3,278 patients with stage II to III colon cancer, to evaluate the prognostic value of KRAS and BRAF tumor mutation status in this setting. PATIENTS AND METHODS: Formalin-fixed paraffin-embedded tissue...

Topics

Adenocarcinoma
Adolescent
Adult
Aged
Colonic Neoplasms
Female
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Prognosis

Prospective Studies

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Young Adult

ras Proteins

Source

Open in PubMed

Identifiers

PMID: 20008640
DOI: 10.1200/JCO.2009.23.3452

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20008640-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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