Article
Microsatellite Instability and KRAS Mutation in Stage IV Colorectal Cancer: Prevalence, Geographic Discrepancies, and Outcomes From the National Cancer Database.
Journal of the National Comprehensive Cancer Network : JNCCN - 2 Feb 2021
Uhlig Johannes, Cecchini Michael, Sheth Amar, Stein Stacey, Lacy Jill, Kim Hyun S
Abstract excerpt
BACKGROUND: This study sought to assess microsatellite and KRAS status, prevalence, and impact on outcome in stage IV colorectal cancer (CRC). MATERIALS AND METHODS: The 2010 to 2016 US National Cancer Database was queried for adult patients with stage IV CRC. Prevalence of microsatellite status (microsatellite instability-high [MSI-H] or microsatellite stable [MSS]) and KRAS status (KRAS mutation or wild-type)...
Topics
- Colorectal Neoplasms
- Humans
- Microsatellite Instability
- Mutation
- Neoplasm Staging
- Prevalence
- Prognosis
- Proto-Oncogene Proteins p21(ras)
- United States