Article
KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer.
Annals of surgical oncology - 1 Feb 2010
Nash Garrett M, Gimbel Mark, Cohen Alfred M, Zeng Zhao-Shi, Ndubuisi Mackevin I, Nathanson Daniel R, Ott Jurg, Barany Francis, Paty Philip B
Abstract excerpt
INTRODUCTION: We examined two genetic markers established early in colorectal tumor development, microsatellite instability (MSI) and mutation of the KRAS proto-oncogene, to see if these genetic changes influence metastatic disease progression and survival. PATIENTS AND METHODS: MSI and KRAS mutation status were assessed in 532 primary adenocarcinomas (stage I-IV) from patients treated by colon resection. Median...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Colon
- Colorectal Neoplasms
- Disease Progression
- Female
- Follow-Up Studies
- Genetic Markers
- Humans