Prognostic and clinicopathologic significance of BRAF mutation in colon cancer by MSI status and stage: A large cohort analysis.

doi:10.1016/j.suronc.2026.102419

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Prognostic and clinicopathologic significance of BRAF mutation in colon cancer by MSI status and stage: A large cohort analysis.

Surgical oncology - 1 Jun 2026

El Sayed Mohyeddine, Youssef Sassine, Shealy Miller W, El Harati Melhem

Abstract excerpt

BACKGROUND: BRAF mutation is a clinically important molecular alteration in colon cancer, but its prognostic significance varies and remains incompletely defined across disease stage and microsatellite instability (MSI) status. This study evaluates the prognostic impact of BRAF mutation and its association with tumor characteristics that may explain its context-dependent behavior. METHODS: Adults with stage I-IV...

Topics

Humans
Proto-Oncogene Proteins B-raf
Microsatellite Instability
Colonic Neoplasms
Prognosis
Mutation
Female
Male
Neoplasm Staging
Survival Rate
Aged
Biomarkers, Tumor
Middle Aged
Follow-Up Studies

Source

Open in PubMed

Identifiers

PMID: 41946229
DOI: 10.1016/j.suronc.2026.102419

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics