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Article

Prognostic significance of KRAS, NRAS, BRAF, and PIK3CA mutations in stage II/III colorectal cancer: A retrospective study and meta-analysis.

PloS one - 1 Jan 2025

Kang Di, Li Jing, Li Yangyang, Xu Jingquan, Yang Jianlei, Zhang Zili

Abstract excerpt

The prognostic significance of KRAS and BRAF mutations is well-established in metastatic colorectal cancer (CRC) but remains uncertain in early-stage tumors. This study retrospectively analyzed 47 stage II/III CRC patients undergoing curative surgery to assess the association of mutations in KRAS, NRAS, BRAF, and PIK3CA with overall survival (OS) and disease-free survival (DFS). Additionally, a meta-analysis was...

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Identifiers

PMID: 40279317
DOI: 10.1371/journal.pone.0320783
PMCID: PMC12027030

Genes

BRAF
KRAS
PIK3CA
NRAS

Provenance

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