Article
Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2012
Ogino Shuji, Shima Kaori, Meyerhardt Jeffrey A, McCleary Nadine J, Ng Kimmie, Hollis Donna, Saltz Leonard B, Mayer Robert J, Schaefer Paul, Whittom Renaud, Hantel Alexander, Benson Al B, Spiegelman Donna, Goldberg Richard M, Bertagnolli Monica M, Fuchs Charles S
Abstract excerpt
PURPOSE: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with microsatellite instability (MSI), and typically predicts inferior prognosis. We examined the effect of BRAF mutation on survival and treatment efficacy in patients with stage III colon cancer. METHODS: We assessed status of BRAF c.1799T>A...
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