Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803.

doi:10.1158/1078-0432.CCR-11-2246

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Article

Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2012

Ogino Shuji, Shima Kaori, Meyerhardt Jeffrey A, McCleary Nadine J, Ng Kimmie, Hollis Donna, Saltz Leonard B, Mayer Robert J, Schaefer Paul, Whittom Renaud, Hantel Alexander, Benson Al B, Spiegelman Donna, Goldberg Richard M, Bertagnolli Monica M, Fuchs Charles S

Abstract excerpt

PURPOSE: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major drivers in colorectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with microsatellite instability (MSI), and typically predicts inferior prognosis. We examined the effect of BRAF mutation on sur...

Topics

Aged
Antineoplastic Combined Chemotherapy Protocols
Camptothecin
Chemotherapy, Adjuvant
Colonic Neoplasms
Disease-Free Survival
Female
Fluorouracil
Humans
Irinotecan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kaplan-Meier Estimate

Leucovorin

Male

Middle Aged

Mutation

Neoplasm Staging

Prognosis

Proportional Hazards Models

Source

Open in PubMed Open full text

Identifiers

PMID: 22147942
DOI: 10.1158/1078-0432.CCR-11-2246
PMCID: PMC3271172

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-22147942-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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