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Article

Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA.

Nature communications - 16 Sept 2015

Izumchenko Evgeny, Chang Xiaofei, Brait Mariana, Fertig Elana, Kagohara Luciane T, Bedi Atul, Marchionni Luigi, Agrawal Nishant, Ravi Rajani, Jones Sian, Hoque Mohammad O, Westra William H, Sidransky David

Abstract excerpt

Lungs resected for adenocarcinomas often harbour minute discrete foci of cytologically atypical pneumocyte proliferations designated as atypical adenomatous hyperplasia (AAH). Evidence suggests that AAH represents an initial step in the progression to adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and fully invasive adenocarcinoma. Despite efforts to identify predictive markers of malignant...

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Topics

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Share to Adenocarcinoma
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to ErbB Receptors

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Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 26374070
DOI: 10.1038/ncomms9258
PMCID: PMC4595648

Genes

EGFR
KRAS
MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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