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Article

Genomic and transcriptomic dynamics in the stepwise progression of lung adenocarcinoma.

Cell research - 1 Dec 2025

Fu Fangqiu, Shang Jun, Yan Yueren, Jiang He, Han Han, Yuan Hui, Gao Zhendong, Yang Jingcheng, Gao Jian, Wang Jun, Pan Yunjian, Lin Yicong, Ye Ting, Zhang Yiliang, Zhang Yawei, Xiang Jiaqing, Hu Hong, Cao Zhiwei, Zheng Yuanting, Li Yuan, Zhang Yang, Jin Li, Shi Leming, Chen Haiquan

Abstract excerpt

Lung adenocarcinoma (LUAD) progresses from pre-invasive to invasive stages, as well as from ground-glass opacities (GGOs) to solid nodules. However, the dynamic genomic and transcriptomic changes underlying LUAD progression are incompletely understood. Here, we performed whole-genome and transcriptome sequencing on 1008 LUAD samples from 954 patients who underwent surgery at Fudan University Shanghai Cancer...

Read the complete abstract on PubMed

Topics

Humans
Adenocarcinoma of Lung
Lung Neoplasms
Disease Progression
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Transcriptome

Mutation

Genomics

Middle Aged

Aged

Genomic Instability

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 41345544
DOI: 10.1038/s41422-025-01200-w
PMCID: PMC12689645

Genes

TP53
EGFR
KEAP1
KMT2D
KRAS
MAP2K1
MGA
MIA
RB1
RBM10
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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