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Article

Genomic Landscape of Atypical Adenomatous Hyperplasia Reveals Divergent Modes to Lung Adenocarcinoma.

Cancer research - 15 Nov 2017

Sivakumar Smruthy, Lucas F Anthony San, McDowell Tina L, Lang Wenhua, Xu Li, Fujimoto Junya, Zhang Jianjun, Futreal P Andrew, Fukuoka Junya, Yatabe Yasushi, Dubinett Steven M, Spira Avrum E, Fowler Jerry, Hawk Ernest T, Wistuba Ignacio I, Scheet Paul, Kadara Humam

Abstract excerpt

There is a dearth of knowledge about the pathogenesis of premalignant lung lesions, especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the major lung cancer subtype adenocarcinoma (LUAD). In this study, we performed deep DNA and RNA sequencing analyses of a set of AAH, LUAD, and normal tissues. Somatic BRAF variants were found in AAHs from 5 of 22 (23%) patients, 4 of 5 of whom...

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Identifiers

PMID: 28951454
DOI: 10.1158/0008-5472.CAN-17-1605
PMCID: PMC5774855

Genes

BRAF
KRAS
AXL
CCR2
EGFR
GZMB
MAX
REL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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