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Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma

5 Jul 2019

Abstract excerpt

There has been a dramatic increase in the detection of lung nodules, many of which are preneoplasia atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) or invasive adenocarcinoma (ADC). The molecular landscape and the evolutionary trajectory of lung preneoplasia have not been well defined. Here, we perform multi-region exome sequencing of 116 resected lung...

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PMID: 31278276
DOI: 10.1038/s41467-019-10877-8

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