Article
Multiomics Analysis Reveals Molecular Changes during Early Progression of Precancerous Lesions to Lung Adenocarcinoma in Never-Smokers.
Cancer research - 1 Feb 2025
Chen Yun-Ching, Hsu Chia-Lang, Wang Hui-Min, Wu Shang-Gin, Chang Yih-Leong, Chen Jin-Shing, Wu Yu-Ching, Lin Yen-Ting, Yang Ching-Yao, Lin Mong-Wei, Lee Jang-Ming, Kuo Shuenn-Wen, Chen Ke-Cheng, Hsu Hsao-Hsun, Huang Pei-Ming, Huang Yen-Lin, Yu Chong-Jen, Pirooznia Mehdi, Huang Bevan E, Yang Rob, Shih Jin-Yuan, Yang Pan-Chyr
Abstract excerpt
Lung cancer is the most common cause of cancer mortality globally, and the prevalence of lung adenocarcinoma, the most common lung cancer subtype, has increased sharply in East Asia. Early diagnosis leads to better survival rates, but this requires an improved understanding of the molecular changes during early tumorigenesis, particularly in nonsmokers. In this study, we performed whole-exome sequencing and RNA...
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