Article
The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.
Infection and immunity - 1 Dec 2015
Shourian Mitra, Flaczyk Adam, Angers Isabelle, Mindt Barbara C, Fritz Jörg H, Qureshi Salman T
Abstract excerpt
The genetic basis of natural susceptibility to progressive Cryptococcus neoformans infection is not well understood. Using C57BL/6 and CBA/J inbred mice, we previously identified three chromosomal regions associated with C. neoformans susceptibility (Cnes1, Cnes2, and Cnes3). To validate and characterize the role of Cnes2 during the host response, we constructed a congenic strain on the C57BL/6 background...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Chromosomes, Mammalian
- Crosses, Genetic
- Cryptococcosis
- Cryptococcus neoformans
- Dendritic Cells
- Gene Expression
- Genetic Loci
- Genetic Predisposition to Disease