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Macrophage-Derived Osteopontin Influences the Amplification of Cryptococcus neoformans–Promoting Type 2 Immune Response

15 Sept 2021

Abstract excerpt

Abstract A multifunctional glycoprotein, osteopontin (OPN), can modulate the function of macrophages, resulting in either protective or deleterious effects in various inflammatory diseases and infection in the lungs. Although macrophages play the critical roles in mediating host defenses against cryptococcosis or cryptococcal pathogenesis, the involvement of macrophage-derived OPN in pulmonary infection caused by...

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PMID: 34526375
DOI: 10.4049/jimmunol.2100202

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