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Article

Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.

Infection and immunity - 1 Dec 2012

Carroll Scott F, Lafferty Erin I, Flaczyk Adam, Fujiwara T Mary, Homer Robert, Morgan Kenneth, Loredo-Osti J C, Qureshi Salman T

Abstract excerpt

Genetic factors that regulate the pathogenesis of pneumonia caused by the fungus Cryptococcus neoformans are poorly understood. Through a phenotypic strain survey we observed that inbred C3H/HeN mice develop a significantly greater lung fungal burden than mice of the resistant CBA/J strain 4 weeks following intratracheal infection with C. neoformans ATCC 24067. The aim of the present study was to characterize the...

Topics

Animals
Chromosomes, Mammalian
Cryptococcosis
Cryptococcus neoformans
Cytokines
Genetic Predisposition to Disease
Lung
Lung Diseases, Fungal
Mice
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred CBA

Quantitative Trait Loci

Th1 Cells

Th2 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 22988020
DOI: 10.1128/IAI.00417-12
PMCID: PMC3497416

Genes

CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22988020-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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