Article
Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants.
mBio - 6 Oct 2015
Zhai Bing, Wozniak Karen L, Masso-Silva Jorge, Upadhyay Srijana, Hole Camaron, Rivera Amariliz, Wormley Floyd L, Lin Xiaorong
Abstract excerpt
UNLABELLED: Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal pathogens. Cryptococcus neoformans, the major causative agent of cryptococcal meningitis, mostly presents as the yeast form but is capable of switching to the hyphal form. The filamentous form has long been associated with attenuated virulence, yet the underlying mechanism remains elusive. We previously identified...
Topics
- Animals
- Cryptococcosis
- Cryptococcus neoformans
- Disease Models, Animal
- Fungal Vaccines
- Gene Expression Regulation, Fungal
- Hyphae
- Immunity, Cellular
- Inflammation
- Mice
- Mutation
- Survival Analysis
- Vaccines, Attenuated