Article
Sex differences in the genetic architecture of susceptibility to Cryptococcus neoformans pulmonary infection.
Genes and immunity - 1 Sept 2008
Carroll S F, Loredo Osti J C, Guillot L, Morgan K, Qureshi S T
Abstract excerpt
Cryptococcus neoformans is a major cause of fungal pneumonia, meningitis and disseminated disease in the immune compromised host. Here we have used a clinically relevant model to investigate the genetic determinants of susceptibility to progressive cryptococcal pneumonia in C57BL/6J and CBA/J inbred mice. At 5 weeks after infection, the lung fungal burden was over 1000-fold higher in C57BL/6J compared to CBA/J...
Topics
- Animals
- Cryptococcosis
- Cryptococcus neoformans
- Female
- Genetic Predisposition to Disease
- Immunity, Innate
- Lung
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA