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Article

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells.

Journal of molecular cell biology - 19 Sept 2019

Zhang Yue, Wang Chao, Liu Xiaoxu, Yang Qian, Ji Hongliang, Yang Mengjun, Xu Manman, Zhou Yunyan, Xie Wei, Luo Zhuojuan, Lin Chengqi

Abstract excerpt

X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression. In female mammals, mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript (XIST) is essential for initiation of X chromosome inactivation upon differentiation. We have previously demonstrated that the central factor of super elongation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 30535390
DOI: 10.1093/jmcb/mjy074
PMCID: PMC7727261

Genes

AFF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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