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Article

NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.

The Journal of biological chemistry - 21 Nov 2014

Ginsburg Daniel S, Anlembom Timi Elvuchio, Wang Jianing, Patel Sanket R, Li Bing, Hinnebusch Alan G

Abstract excerpt

Cotranscriptional methylation of histone H3 lysines 4 and 36 by Set1 and Set2, respectively, stimulates interaction between nucleosomes and histone deacetylase complexes to block cryptic transcription in budding yeast. We previously showed that loss of all H3K4 and H3K36 methylation in a set1Δset2Δ mutant reduces interaction between native nucleosomes and the NuA4 lysine acetyltransferase (KAT) complex. We now...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25301943
DOI: 10.1074/jbc.M114.585588
PMCID: PMC4239618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.PMID 25301943Read ↗

NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.Semantic proximity Read ↗

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.Semantic proximity Read ↗

A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.Semantic proximity Read ↗

Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

ATAC and SAGA histone acetyltransferase modules facilitate transcription factor binding to nucleosomes in an acetylation independent mannerSemantic proximity Read ↗

Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Semantic proximity Read ↗

Overexpression of Eaf1, a subunit of the NuA4 lysine acetyltransferase complex, rescues growth defects in the <i>Saccharomyces cerevisiae</i> H3K36M oncohistone model via histone H4 tail acetylationSemantic proximity Read ↗

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.Semantic proximity Read ↗

Combined Interactions of Plant Homeodomain and Chromodomain Regulate NuA4 Activity at DNA Double-Strand Breaks.Semantic proximity Read ↗

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