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Article

Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations.

Molecular biology and evolution - 4 Jan 2023

Wooldridge Lydia K, Dumont Beth L

Abstract excerpt

Meiotic recombination is an important evolutionary force and an essential meiotic process. In many species, recombination events concentrate into hotspots defined by the site-specific binding of PRMD9. Rapid evolution of Prdm9's zinc finger DNA-binding array leads to remarkably abrupt shifts in the genomic distribution of hotspots between species, but the question of how Prdm9 allelic variation shapes the...

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PMID: 36508360
DOI: 10.1093/molbev/msac267
PMCID: PMC9825251

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