Article
Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.
Journal of gastroenterology - 1 May 2016
Kawaguchi Yasuo, Hinoi Takao, Saito Yasufumi, Adachi Tomohiro, Miguchi Masashi, Niitsu Hiroaki, Sasada Tatsunari, Shimomura Manabu, Egi Hiroyuki, Oka Shiro, Tanaka Shinji, Chayama Kazuaki, Sentani Kazuhiro, Oue Naohide, Yasui Wataru, Ohdan Hideki
Abstract excerpt
BACKGROUND: KRAS gene mutations are found in 40-50% of colorectal cancer cases, but their functional contribution is not fully understood. To address this issue, we generated genetically engineered mice with colon tumors expressing an oncogenic Kras(G12D) allele in the context of the Adenomatous polyposis coli (Apc) deficiency to compare them to tumors harboring Apc deficiency alone. METHODS: CDX2P9.5-G22Cre...
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