Article
Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.
PloS one - 1 Jan 2016
Miguchi Masashi, Hinoi Takao, Shimomura Manabu, Adachi Tomohiro, Saito Yasufumi, Niitsu Hiroaki, Kochi Masatoshi, Sada Haruki, Sotomaru Yusuke, Ikenoue Tsuneo, Shigeyasu Kunitoshi, Tanakaya Kohji, Kitadai Yasuhiko, Sentani Kazuhiro, Oue Naohide, Yasui Wataru, Ohdan Hideki
Abstract excerpt
Mutations in TGFBR2, a component of the transforming growth factor (TGF)-β signaling pathway, occur in high-frequency microsatellite instability (MSI-H) colorectal cancer (CRC). In mouse models, Tgfbr2 inactivation in the intestinal epithelium accelerates the development of malignant intestinal tumors in combination with disruption of the Wnt-β-catenin pathway. However, no studies have further identified the...
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