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Article

Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer.

International journal of molecular sciences - 13 Nov 2019

Maitra Radhashree, Thavornwatanayong Thongthai, Venkatesh Madhu Kumar, Chandy Carol, Vachss Dov, Augustine Titto, Guzik Hillary, Koba Wade, Liu Qiang, Goel Sanjay

Abstract excerpt

Patients with KRAS mutated colorectal cancer (CRC) represent a cohort with unmet medical needs, with limited options of FDA-approved therapies. Representing 40-45% of all CRC patients, they are considered ineligible to receive anti-EGFR monoclonal antibodies that have added a significant therapeutic benefit for KRAS wild type CRC patients. Although several mouse models of CRC have been developed during the past...

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Identifiers

PMID: 31766149
DOI: 10.3390/ijms20225677
PMCID: PMC6888417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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