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Article

A Novel CRISPR/Cas9-mediated Mouse Model of Colon Carcinogenesis.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2024

Kashima Hajime, Fischer Anthony, Veronese-Paniagua Daniel A, Gazit Vered A, Ma Changqing, Yan Yan, Levin Marc S, Madison Blair B, Rubin Deborah C

Abstract excerpt

BACKGROUND & AIMS: Human sporadic colorectal cancer (CRC) results from a multistep pathway with sequential acquisition of specific genetic mutations in the colorectal epithelium. Modeling CRC in vivo is critical for understanding the tumor microenvironment. To accurately recapitulate human CRC pathogenesis, mouse models must include these multi-step genetic abnormalities. The aim of this study was to generate a...

Topics

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Carcinogenesis
Colonic Neoplasms
CRISPR-Cas Systems
Disease Models, Animal
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Tumor Suppressor

Mice, Transgenic

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Open in PubMed Open full text

Identifiers

PMID: 39128652
DOI: 10.1016/j.jcmgh.2024.101390
PMCID: PMC11462267

Genes

PLAGL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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