Article

Genetically induced mouse model for colon-specific epithelial cell tumorigenesis driven by loss of K8 and Apc

2025-02-07

Abstract excerpt

Loss of keratin 8 (K8) has been shown to increase susceptibility towards colonocyte hyperproliferation and tumorigenesis. However, most colorectal cancer (CRC) mouse models require carcinogen, develop small intestinal tumors or have long latency period. The aim was to establish a genetic, colon-specific and more human like CRC model driven by loss of K8 and Apc. Colon epithelium specific targeting using the CDX2P-...

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Literature Corpus work: 8d5895af-8349-5d71-8654-ab8feeeb8a09
DOI: 10.1101/2025.02.03.635623

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