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Article

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras.

Cancer letters - 1 Jun 2014

Byun Alexander J, Hung Kenneth E, Fleet James C, Bronson Roderick T, Mason Joel B, Garcia Paloma E, Crott Jimmy W

Abstract excerpt

Several genetically engineered mouse (GEM) models of colorectal cancer have been developed and are a mainstay in our efforts to identify means of preventing and treating this disease. Many of these models involve a germline disruption of the adenomatous polyposis coli (Apc) tumor suppressor gene and share the limitation that the great preponderance of tumors appear in the small rather than large intestine. In...

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Identifiers

PMID: 24632531
DOI: 10.1016/j.canlet.2014.03.004
PMCID: PMC4418438

Genes

GEM

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