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Article

A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2015

Choi Sangwook, Camp Sara M, Dan Arkaprava, Garcia Joe G N, Dudek Steven M, Leckband Deborah E

Abstract excerpt

Inflammatory mediators released in acute lung injury (ALI) trigger the disruption of interendothelial junctions, leading to loss of vascular barrier function, protein-rich pulmonary edema, and severe hypoxemia. Genetic signatures that predict patient recovery or disease progression are poorly defined, but recent genetic screening of ALI patients has identified an association between lung inflammatory disease and...

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Identifiers

PMID: 26361873
DOI: 10.1152/ajplung.00062.2015
PMCID: PMC4628987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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