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Article

Candidate genetic and multi-omics determinants potentially contributing to Macklin effect development in acute respiratory distress syndrome: A narrative review.

Gene - 5 Nov 2026

Radice Rosa Paola, Vignola Federica, Montagnuolo Xavier, Belletti Alessandro, Paternoster Gianluca, Martelli Giuseppe

Abstract excerpt

BACKGROUND: Acute respiratory distress syndrome (ARDS) is a complex and heterogeneous clinical syndrome characterized by diffuse alveolar damage, severe hypoxemia, and a high risk of respiratory complications. Among these, the Macklin effect has emerged as an early radiological sign associated with the subsequent development of barotrauma. Although several genetic and molecular factors have been implicated in...

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Identifiers

PMID: 42323114
DOI: 10.1016/j.gene.2026.150276

Genes

CCL2
MMP8
PTX3
S1PR3
TIMP1
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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