Article
Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.
Disease models & mechanisms - 1 Apr 2017
Poobalasingam Thanushiyan, Yates Laura L, Walker Simone A, Pereira Miguel, Gross Nina Y, Ali Akmol, Kolatsi-Joannou Maria, Jarvelin Marjo-Riitta, Pekkanen Juha, Papakrivopoulou Eugenia, Long David A, Griffiths Mark, Wagner Darcy, Königshoff Melanie, Hind Matthew, Minelli Cosetta, Lloyd Clare M, Dean Charlotte H
Abstract excerpt
Lung diseases impose a huge economic and health burden worldwide. A key aspect of several adult lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), including emphysema, is aberrant tissue repair, which leads to an accumulation of damage and impaired respiratory function. Currently, there are few effective treatments available for these diseases and their...
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