Article

Alveolar epithelium propagates mechanical signals that control multi-cellular homeostasis in the lung

2025-06-05

Abstract excerpt

Respiratory motion imposes a constant mechanical strain that has important but poorly defined impact on tissue niches in the lung. We developed a reversible bronchial ligation model to induce and reverse unilateral blockade of lung mechanical motion in vivo and show that this leads to transcriptomic changes in multiple cell lineages that are not normalized upon reinitiation of respiratory motion. Perturbation of...

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Literature Corpus work: 2f16a913-8e82-56ed-9bcd-b750614f55ec
DOI: 10.1101/2025.06.04.657878

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