A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects.

doi:10.1016/j.trsl.2022.02.002

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Article

A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects.

Translational research : the journal of laboratory and clinical medicine - 1 Jun 2022

Belvitch Patrick, Casanova Nancy, Sun Xiaoguang, Camp Sara M, Sammani Saad, Brown Mary E, Mascarhenas Joseph, Lynn Heather, Adyshev Djanybek, Siegler Jessica, Desai Ankit, Seyed-Saadat Laleh, Rizzo Alicia, Bime Christian, Shekhawat Gajendra S, Dravid Vinayak P, Reilly John P, Jones Tiffanie K, Feng Rui, Letsiou Eleftheria, Meyer Nuala J, Ellis Nathan, Garcia Joe G N, Dudek Steven M

Abstract excerpt

The cortactin gene (CTTN), encoding an actin-binding protein critically involved in cytoskeletal dynamics and endothelial cell (EC) barrier integrity, contains single nucleotide polymorphisms (SNPs) associated with severe asthma in Black patients. As loss of lung EC integrity is a major driver of mortality in the Acute Respiratory Distress Syndrome (ARDS), sepsis, and the acute chest syndrome (ACS), we speculated...

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Identifiers

PMID: 35181549
DOI: 10.1016/j.trsl.2022.02.002
PMCID: PMC9119916

Genes

CTTN
SCD

Variants

rs56162978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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