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Article

Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells

2 Feb 2023

Abstract excerpt

Blood flow produces shear stress that homeostatically regulates the phenotype of pulmonary endothelial cells, exerting antiinflammatory and antithrombotic actions and maintaining normal barrier function. Hypoxia due to diseases, such as chronic obstructive pulmonary disease (COPD), causes vasoconstriction, increased vascular resistance, and pulmonary hypertension. Hypoxia-induced changes in endothelial function...

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Share to Cancer, Hypoxia, and Metabolism
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Identifiers

PMID: 36730645
DOI: 10.1165/rcmb.2022-0340oc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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