Article

Modeling Endothelial Dysfunction in Idiopathic Pulmonary Fibrosis: Bridging Mechanistic Insights and Translational Applications

2025-09-30

Abstract excerpt

The alveolus, the lung’s primary gas exchange unit, relies on tightly coordinated interactions between epithelial and endothelial layers. In idiopathic pulmonary fibrosis (IPF), a progressive interstitial lung disease, this architecture is profoundly disrupted. While epithelial and mesenchymal compartments have been extensively studied, the role of pulmonary microvascular endothelial cells (PMVECs) in IPF pathogen...

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Literature Corpus work: 967e16e7-ca6c-56d8-b8bc-bda855afd2b9
DOI: 10.1101/2025.09.29.679236

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