Article
Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Sept 2015
Pujol-Borrell R, Giménez-Barcons M, Marín-Sánchez A, Colobran R
Abstract excerpt
As most autoimmune diseases, inherited predisposition to Graves' disease (GD) is polygenic with the main contributory genes being located in the HLA region. Also, as in other autoimmune diseases, family linkage, candidate gene association, and GWAS studies have identified an expanding number of predisposing genes (CTLA4, CD40, PTPN22...) and 2 of them, TG and TSHR, are thyroid specific. In spite of this expanding...
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