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Article

Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.

Human molecular genetics - 1 Sept 2011

Colobran Roger, Armengol Maria Del Pilar, Faner Rosa, Gärtner Martina, Tykocinski Lars-Oliver, Lucas Anna, Ruiz Marta, Juan Manel, Kyewski Bruno, Pujol-Borrell Ricardo

Abstract excerpt

Graves' disease (GD) is the paradigm of an anti-receptor autoimmune disease, with agonistic auto-antibodies against the thyrotropin receptor (TSHR-thyroid-stimulating hormone receptor) being the underlying pathogenic effector mechanism. The TSHR belongs to the category of tissue-restricted antigens, which are promiscuously expressed in the thymus and thereby induce central T cell tolerance. In order to understand...

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Source

Identifiers

PMID: 21642385
DOI: 10.1093/hmg/ddr247

Genes

TSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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