Article
Association of the TSHR gene with Graves' disease: the first disease specific locus.
European journal of human genetics : EJHG - 1 Nov 2005
Dechairo Bryan M, Zabaneh Delilah, Collins Joanne, Brand Oliver, Dawson Gary J, Green Angie P, Mackay Ian, Franklyn Jayne A, Connell John M, Wass John A H, Wiersinga Wilmar M, Hegedus Laszlo, Brix Thomas, Robinson Bruce G, Hunt Penny J, Weetman Anthony P, Carey Alisoun H, Gough Stephen C
Abstract excerpt
The development of autoimmune thyroid disease (AITD) is associated with autoantibodies directed against the thyroid stimulating hormone receptor (TSHR). Previous studies have failed to demonstrate a consistent association between the TSHR and AITD, or any of its sub-phenotypes. In the present study, we analysed the linkage disequilibrium (LD) structure encompassing the TSHR, to identify LD 'blocks' and SNPs,...
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