Article
Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease.
Human molecular genetics - 1 May 2009
Brand Oliver J, Barrett Jeffrey C, Simmonds Matthew J, Newby Paul R, McCabe Christopher J, Bruce Christopher K, Kysela Boris, Carr-Smith Jackie D, Brix Thomas, Hunt Penny J, Wiersinga Wilmar M, Hegedüs Laszlo, Connell John, Wass John A H, Franklyn Jayne A, Weetman Anthony P, Heward Joanne M, Gough Stephen C L
Abstract excerpt
Graves' disease (GD) is a common autoimmune disease (AID) that shares many of its susceptibility loci with other AIDs. The thyroid stimulating hormone receptor (TSHR) represents the primary autoantigen in GD, in which autoantibodies bind to the receptor and mimic its ligand, thyroid stimulating hormone, causing the characteristic clinical phenotype. Although early studies investigating the TSHR and GD proved...
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