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Article

Role of genetic and non-genetic factors in the etiology of Graves' disease.

Journal of endocrinological investigation - 1 Mar 2015

Marinò M, Latrofa F, Menconi F, Chiovato L, Vitti P

Abstract excerpt

In spite of the advancements in understanding the pathogenic mechanisms of Graves' disease (GD), its ultimate cause remains elusive. The majority of investigators agree that GD is likely a multifactorial disease, due to a complex interplay of genetic and non-genetic factors that lead to the loss of immune tolerance to thyroid antigens and to the initiation of a sustained autoimmune reaction. Twin and family...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25421156
DOI: 10.1007/s40618-014-0214-2

Genes

FCRL3
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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