Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between polymorphisms in the TSHR gene and Graves' orbitopathy.

PloS one - 1 Jan 2014

Jurecka-Lubieniecka Beata, Ploski Rafal, Kula Dorota, Szymanski Konrad, Bednarczuk Tomasz, Ambroziak Urszula, Hasse-Lazar Kornelia, Hyla-Klekot Lidia, Tukiendorf Andrzej, Kolosza Zofia, Jarzab Barbara

Abstract excerpt

BACKGROUND: Graves' orbitopathy (GO) as well as Graves' disease (GD) hyperthyroidism originate from an autoimmune reaction against the common auto-antigen, thyroid-stimulating hormone receptor (TSHR). GO phenotype is associated with environmental risk factors, mainly nicotinism, as well as genetic risk factors which initiate an immunologic reaction. In some patients GO is observed before diagnosis of GD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Graves Ophthalmopathy

Share to Inflammation

Share to Polymorphism, Single Nucleotide

Share to Receptors, Thyrotropin

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25061884
DOI: 10.1371/journal.pone.0102653
PMCID: PMC4111286

Genes

TSHR
CTLA4
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between polymorphisms in the TSHR gene and Graves' orbitopathy.PMID 25061884Read ↗

TSHR intronic polymorphisms (rs179247 and rs12885526) and their role in the susceptibility of the Brazilian population to Graves' disease and Graves' ophthalmopathy.Semantic proximity Read ↗

Genetic associations of the thyroid stimulating hormone receptor gene with Graves diseases and Graves ophthalmopathy: A meta-analysis.Semantic proximity Read ↗

Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy.Semantic proximity Read ↗

The genetics of the thyroid stimulating hormone receptor: history and relevance.Semantic proximity Read ↗

The genetics of Graves' disease.Semantic proximity Read ↗

TSHR Gene (rs179247) Polymorphism and Susceptibility to Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology.Semantic proximity Read ↗

Risk factors for development or deterioration of Graves' ophthalmopathy.Semantic proximity Read ↗

CTLA4 gene and Graves’ disease: association of Graves’ disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphismSemantic proximity Read ↗

Unravelling the pathogenic mechanisms in Graves’ orbitopathySemantic proximity Read ↗

Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene.Semantic proximity Read ↗

Association of polymorphisms of rs179247 and rs12101255 in thyroid stimulating hormone receptor intron 1 with an increased risk of Graves' disease: A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.