Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality.

doi:10.1371/journal.pgen.1005487

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Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality.

PLoS genetics - 1 Sept 2015

Raffler Johannes, Friedrich Nele, Arnold Matthias, Kacprowski Tim, Rueedi Rico, Altmaier Elisabeth, Bergmann Sven, Budde Kathrin, Gieger Christian, Homuth Georg, Pietzner Maik, Römisch-Margl Werner, Strauch Konstantin, Völzke Henry, Waldenberger Melanie, Wallaschofski Henri, Nauck Matthias, Völker Uwe, Kastenmüller Gabi, Suhre Karsten

Abstract excerpt

Genome-wide association studies with metabolic traits (mGWAS) uncovered many genetic variants that influence human metabolism. These genetically influenced metabotypes (GIMs) contribute to our metabolic individuality, our capacity to respond to environmental challenges, and our susceptibility to specific diseases. While metabolic homeostasis in blood is a well investigated topic in large mGWAS with over 150 known...

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Identifiers

PMID: 26352407
DOI: 10.1371/journal.pgen.1005487
PMCID: PMC4564198

Genes

CPS1
XYLB
ACSM3
AGXT
DMGDH
ETNPPL
GLDC
HIBCH
PNMT
TKT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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