Human metabolic individuality in biomedical and pharmaceutical research.

doi:10.1038/nature10354

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Article

Human metabolic individuality in biomedical and pharmaceutical research.

Nature - 31 Aug 2011

Suhre Karsten, Shin So-Youn, Petersen Ann-Kristin, Mohney Robert P, Meredith David, Wägele Brigitte, Altmaier Elisabeth, Deloukas Panos, Erdmann Jeanette, Grundberg Elin, Hammond Christopher J, de Angelis Martin Hrabé, Kastenmüller Gabi, Köttgen Anna, Kronenberg Florian, Mangino Massimo, Meisinger Christa, Meitinger Thomas, Mewes Hans-Werner, Milburn Michael V, Prehn Cornelia, Raffler Johannes, Ried Janina S, Römisch-Margl Werner, Samani Nilesh J, Small Kerrin S, Wichmann H-Erich, Zhai Guangju, Illig Thomas, Spector Tim D, Adamski Jerzy, Soranzo Nicole, Gieger Christian

Abstract excerpt

Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking. Associations with metabolic traits as functional intermediates can overcome these problems and potentially inform individualized therapy. Here we report a comprehensive analysis of genotype-dependent metabolic...

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PMID: 21886157
DOI: 10.1038/nature10354
PMCID: PMC3832838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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