Article
Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program.
American journal of human genetics - 6 Nov 2025
Wang Nannan, Ockerman Franklin P, Zhou Laura Y, Grove Megan L, Alkis Taryn, Barnard John, Bowler Russell P, Clish Clary B, Chung Shinhye, Drzymalla Emily, Evans Anne M, Franceschini Nora, Gerszten Robert E, Gillman Madeline G, Hutton Scott R, Kelly Rachel S, Kooperberg Charles, Larson Martin G, Lasky-Su Jessica, Meyers Deborah A, Woodruff Prescott G, Reiner Alexander P, Rich Stephen S, Rotter Jerome I, Silverman Edwin K, Vasan Ramachandran S, Weiss Scott T, Wong Kari E, Wood Alexis C, Wu Lang, Yarden Ronit, Blackwell Thomas W, Smith Albert V, Chen Han, Raffield Laura M, Yu Bing
Abstract excerpt
Circulating metabolite levels partly reflect the state of human health and diseases and can be impacted by genetic determinants. Hundreds of loci associated with circulating metabolites have been identified; however, most findings focus on predominantly European ancestry or single-study analyses. Leveraging the rich metabolomics resources generated by the National Heart, Lung, and Blood Institute (NHLBI)...
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