Article
Rare and common genetic determinants of metabolic individuality and their effects on human health.
Nature medicine - 1 Nov 2022
Surendran Praveen, Stewart Isobel D, Au Yeung Victoria P W, Pietzner Maik, Raffler Johannes, Wörheide Maria A, Li Chen, Smith Rebecca F, Wittemans Laura B L, Bomba Lorenzo, Menni Cristina, Zierer Jonas, Rossi Niccolò, Sheridan Patricia A, Watkins Nicholas A, Mangino Massimo, Hysi Pirro G, Di Angelantonio Emanuele, Falchi Mario, Spector Tim D, Soranzo Nicole, Michelotti Gregory A, Arlt Wiebke, Lotta Luca A, Denaxas Spiros, Hemingway Harry, Gamazon Eric R, Howson Joanna M M, Wood Angela M, Danesh John, Wareham Nicholas J, Kastenmüller Gabi, Fauman Eric B, Suhre Karsten, Butterworth Adam S, Langenberg Claudia
Abstract excerpt
Garrod's concept of 'chemical individuality' has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolome using 913 metabolites assayed in 19,994 individuals and identified 2,599 variant-metabolite associations...
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