Article
A genome-wide association study of metabolic traits in human urine.
Nature genetics - 1 Jun 2011
Suhre Karsten, Wallaschofski Henri, Raffler Johannes, Friedrich Nele, Haring Robin, Michael Kathrin, Wasner Christina, Krebs Alexander, Kronenberg Florian, Chang David, Meisinger Christa, Wichmann H-Erich, Hoffmann Wolfgang, Völzke Henry, Völker Uwe, Teumer Alexander, Biffar Reiner, Kocher Thomas, Felix Stephan B, Illig Thomas, Kroemer Heyo K, Gieger Christian, Römisch-Margl Werner, Nauck Matthias
Abstract excerpt
We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992...
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