Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.

doi:10.1371/journal.pgen.1004132

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Article

Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.

PLoS genetics - 1 Feb 2014

Rueedi Rico, Ledda Mirko, Nicholls Andrew W, Salek Reza M, Marques-Vidal Pedro, Morya Edgard, Sameshima Koichi, Montoliu Ivan, Da Silva Laeticia, Collino Sebastiano, Martin François-Pierre, Rezzi Serge, Steinbeck Christoph, Waterworth Dawn M, Waeber Gérard, Vollenweider Peter, Beckmann Jacques S, Le Coutre Johannes, Mooser Vincent, Bergmann Sven, Genick Ulrich K, Kutalik Zoltán

Abstract excerpt

Metabolic traits are molecular phenotypes that can drive clinical phenotypes and may predict disease progression. Here, we report results from a metabolome- and genome-wide association study on (1)H-NMR urine metabolic profiles. The study was conducted within an untargeted approach, employing a novel method for compound identification. From our discovery cohort of 835 Caucasian individuals who participated in the...

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PMID: 24586186
DOI: 10.1371/journal.pgen.1004132
PMCID: PMC3930510

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