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Genetic atlas of plasma metabolome across 40 human common diseases: mapping causal metabolites to disease risk.

Genome medicine - 22 Nov 2025

Li Yanmin, Cai Yimin, Ma Qianying, Yang Xiaojun, He Chunyi, Xu Ying, Zhang Ming, Lu Zequn, Chen Can, Ning Caibo, Liu Bo, Wei Yongchang, Li Xiangpan, Jin Meng, Zhu Xu, Li Bin, Zhu Ying, Huang Chaoqun, Miao Xiaoping, Tian Jianbo

Abstract excerpt

BACKGROUND: Metabolites are closely linked to individual health and disease conditions. Identifying genetic factors influencing metabolite levels in specific diseases can enhance our understanding of disease etiology and informing precision medicine. This study aims to characterize the genetic architecture of metabolites in specific disease states and explore their potential biological functions. METHODS: We...

Topics

Humans
Quantitative Trait Loci
Metabolome
Mendelian Randomization Analysis
Genome-Wide Association Study
Genetic Predisposition to Disease
Disease
Biomarkers

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PMID: 41275212
DOI: 10.1186/s13073-025-01578-7
PMCID: PMC12751435

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