Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.

doi:10.1161/HYPERTENSIONAHA.114.03419

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Article

Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2014

Fernandes-Rosa Fabio Luiz, Williams Tracy Ann, Riester Anna, Steichen Olivier, Beuschlein Felix, Boulkroun Sheerazed, Strom Tim M, Monticone Silvia, Amar Laurence, Meatchi Tchao, Mantero Franco, Cicala Maria-Verena, Quinkler Marcus, Fallo Francesco, Allolio Bruno, Bernini Giampaolo, Maccario Mauro, Giacchetti Gilberta, Jeunemaitre Xavier, Mulatero Paolo, Reincke Martin, Zennaro Maria-Christina

Abstract excerpt

Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs). Our aim was to investigate the prevalence of somatic mutations in these genes in unselected patients with APA (n=474), collected through the European Network for the Study of Adrenal Tumors. Correlations with clinical and...

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PMID: 24866132
DOI: 10.1161/HYPERTENSIONAHA.114.03419

Genes

KCNJ5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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